Gingival hyperplasia in rats induced by oxodipine--a calcium channel blocker.

Abstract	Oxodipine, a new calcium channel blocker, induced gingival hyperplasia in rats. This is the first time that a calcium channel blocker has been documented as resulting in gingival hyperplasia in rats. In contrast to diphenylhydantoin, the hyperplastic changes induced by oxodipine were not precipitated by any prior irritation. The histology consisted of purely fibroblastic proliferation without infiltrate of inflammatory cells.
Authors	A Nyska, T Waner, M Pirak, A Galiano, A Zlotogorski
Journal	Journal of periodontal research (J Periodontal Res) Vol. 25 Issue 2 Pg. 65-8 (Mar 1990) ISSN: 0022-3484 [Print] United States
PMID	2139118 (Publication Type: Journal Article)
Chemical References	Calcium Channel Blockers Dihydropyridines oxodipine
Topics	Animals Calcium Channel Blockers (toxicity) Dihydropyridines (toxicity) Disease Models, Animal Female Gingival Hyperplasia (chemically induced, pathology) Male Rats Rats, Inbred F344

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!