HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A human IgG receptor of group A streptococci is associated with tissue site of infection and streptococcal class.

Abstract
The distribution of receptors for immunoglobulins of several different isotypes was examined for group A streptococcal isolates derived from skin and nasopharyngeal sites. Although human IgG-Fc receptor activity was a variable property of group A streptococci, found among 61% of all isolates tested, it was largely restricted to well-defined subpopulations. Human IgG-binding activity was observed among nearly all impetigo isolates examined. In addition, the expression of the class II M protein molecule (one of two broad antigenic classes of the major virulence factor) and opacity factor (a lipoproteinase) was almost invariably accompanied by human IgG binding, regardless of tissue site of infection. In contrast to class I impetigo isolates, class I nasopharyngeal isolates were relatively devoid of human IgG-binding activity. The data suggest that the presence or absence of human IgG-binding activity correlates with certain diseases caused by group A streptococci.
AuthorsD Bessen, V A Fischetti
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 161 Issue 4 Pg. 747-54 (Apr 1990) ISSN: 0022-1899 [Print] United States
PMID2138653 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antigens, Differentiation
  • Immunoglobulin A
  • Immunoglobulin G
  • Receptors, Fc
  • Receptors, IgG
Topics
  • Animals
  • Antigens, Differentiation (analysis)
  • Humans
  • Immunoglobulin A (immunology)
  • Immunoglobulin G (immunology)
  • Impetigo (microbiology)
  • Nasopharynx (microbiology)
  • Rabbits
  • Receptors, Fc (analysis)
  • Receptors, IgG
  • Skin (microbiology)
  • Streptococcal Infections (microbiology)
  • Streptococcus pyogenes (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: