Abstract | INTRODUCTION: AREAS COVERED: The areas covered are: i) an overview of clinical trials of lubiprostone in the treatment of OBD based on peer-reviewed literature and congress materials from 2005 to 2010; and ii) an evaluation of the efficacy and potential mechanisms of action of lubiprostone in the treatment of OBD. EXPERT OPINION:
Lubiprostone has potential in treating OBD and deserves additional study. Lubiprostone's ability to promote fluid secretion locally at the apical membrane of intestinal epithelial cells ensures it does not provoke opioid withdrawal or compromise analgesia. Lubiprostone seems safe for long-term use in CIC patients, and a similar safety profile is anticipated in OBD.
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Authors | Banny S Wong, Michael Camilleri |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 12
Issue 6
Pg. 983-90
(Apr 2011)
ISSN: 1744-7666 [Electronic] England |
PMID | 21385112
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Analgesics, Opioid
- Chloride Channels
- Laxatives
- Lubiprostone
- Alprostadil
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Topics |
- Alprostadil
(analogs & derivatives, therapeutic use)
- Analgesics, Opioid
(adverse effects)
- Chloride Channels
(drug effects)
- Clinical Trials as Topic
- Constipation
(chemically induced, drug therapy)
- Humans
- Laxatives
(therapeutic use)
- Lubiprostone
- Treatment Outcome
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