Abstract |
1,3,5-Trinitroperhydro-1,3,5-triazine ( RDX) is a nitroamine explosive, with common toxic effects including seizures. Here, we explore the behavioral effects of acute RDX exposure in adult zebrafish Danio rerio, a rapidly developing model in neuroscience and neurotoxicology research. Overall, a 30-min exposure to RDX low dose of 0.1 mM evoked behavioral activation in zebrafish, while a higher dose of 1 mM markedly reduced exploration, increased freezing and evoked seizure-like responses (i.e., bouts of hyperactivity, spasms, and corkscrew swimming). Likewise, whole-body cortisol levels were also significantly elevated in fish exposed to 1 mM (but not 0.1 mM) RDX. In line with clinical and animal data, our study demonstrates the dose-dependent behavioral activation and pro- convulsant effects of RDX in zebrafish-based models.
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Authors | Larry R Williams, Keith Wong, Adam Stewart, Christopher Suciu, Siddharth Gaikwad, Nadine Wu, John Dileo, Leah Grossman, Jonathan Cachat, Peter Hart, Allan V Kalueff |
Journal | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
(Comp Biochem Physiol C Toxicol Pharmacol)
Vol. 155
Issue 1
Pg. 33-8
(Jan 2012)
ISSN: 1532-0456 [Print] United States |
PMID | 21382508
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Triazines
- cyclonite
- Hydrocortisone
|
Topics |
- Animals
- Behavior, Animal
(drug effects)
- Female
- Hydrocortisone
(analysis)
- Hyperkinesis
(chemically induced)
- Locomotion
(drug effects)
- Male
- Seizures
(chemically induced)
- Spasm
(chemically induced)
- Swimming
- Time Factors
- Toxicity Tests, Acute
- Triazines
(toxicity)
- Zebrafish
(physiology)
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