HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Anti-allergic activity of sesquiterpenes from the rhizomes of Cyperus rotundus.

Abstract
From the 70% ethanol extract of the rhizomes of Cyperus rotundus (CRE), several major constituents including the sesquiterpene derivatives (valencene, nootkatone, and caryophyllene α-oxide), monoterpenes (β-pinene, 1,8-cineole, and limonene) and 4-cymene were isolated and examined for their anti-allergic activity in vitro and in vivo. In rat basophilic leukemia (RBL)-1 cells, the sesquiterpenes strongly inhibited 5-lipoxygenase-catalyzed leukotrienes production. In addition, they inhibited β-hexosaminidase release by antigen-stimulated RBL-2H3 cells, with valencene having the highest inhibitory effect. CRE inhibited leukotrienes production and β-hexosaminidase release at 300 μg/mL. It was also found that the most active sesquiterpene (valencene) and CRE inhibited β-hexosaminidase degranulation by inhibiting the initial activation reaction, Lyn phosphorylation, in IgE-stimulated RBL-2H3 cells. Moreover, CRE, valencene and nootkatone significantly inhibited the delayed-type hypersensitivity reaction in mice when administered orally at 50-300 mg/kg. In conclusion, C. rotundus and its constituents, valencene, nootkatone, and caryophyllene α-oxide, exert anti-allergic activity in vitro and in vivo. These sesquiterpenes, but not monoterpenes, certainly contribute to the anti-allergic activity of the rhizomes of C. rotundus.
AuthorsJeong Ho Jin, Dong-Ung Lee, Yeong Shik Kim, Hyun Pyo Kim
JournalArchives of pharmacal research (Arch Pharm Res) Vol. 34 Issue 2 Pg. 223-8 (Feb 2011) ISSN: 1976-3786 [Electronic] Korea (South)
PMID21380805 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Allergic Agents
  • Plant Extracts
  • Sesquiterpenes
Topics
  • Animals
  • Anti-Allergic Agents (chemistry, isolation & purification, pharmacology)
  • Cell Degranulation (drug effects)
  • Cyperus
  • Drug Screening Assays, Antitumor
  • Hypersensitivity, Delayed (drug therapy)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Phytotherapy
  • Plant Extracts (chemistry, isolation & purification, pharmacology)
  • Rats
  • Rhizome
  • Sesquiterpenes (chemistry, isolation & purification, pharmacology)
  • Tumor Cells, Cultured

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: