Four cardiac hormones cause death of human cancer cells but not of healthy cells.

Abstract

BACKGROUND:

Four cardiac hormones, namely, vessel dilator, long-acting natriuretic peptide, atrial natriuretic peptide and kaliuretic peptide, have anticancer effects but whether they cause cell death of human cancer cells or normal cells is unknown.

MATERIALS AND METHODS:

These cardiac hormones were examined for their ability to cause cell death quantified by measurement of nuclear matrix proteins 41/7 which is a function of the number of dead or dying cells.

RESULTS:

Each of these cardiac hormones caused cell death in up to 36% (p < 0.0001) of the pancreatic adenocarcinoma cells and up to 28% (p<0.0001) of the prostate cancer cells over a concentration range of 100 pmol/l to 10 μmol/l. There was no cell death of normal human prostate, kidney, or lung cells at the above concentrations.

CONCLUSION:

Four cardiac hormones cause death of pancreatic and prostate cancer cells but not of normal prostate, lung, or kidney cells.

• Authors: William P Skelton 4th, Guillermo E Pi, David L Vesely
• Journal: Anticancer research (Anticancer Res) Vol. 31 Issue 2 Pg. 395-402 (Feb 2011) ISSN: 1791-7530 [Electronic] Greece
• PMID: 21378317 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antigens, Nuclear
• Cell Cycle Proteins
• NUMA1 protein, human
• Nuclear Matrix-Associated Proteins
• Peptide Fragments
• Protein Precursors
• atrial natriuretic factor precursor (79-98)
• atrial natriuretic factor prohormone (1-30), human
• atrial natriuretic factor prohormone (31-67)
• Atrial Natriuretic Factor

Topics

• Adenocarcinoma (drug therapy, metabolism, pathology)
• Aged
• Antigens, Nuclear (metabolism)
• Atrial Natriuretic Factor (pharmacology)
• Cell Cycle Proteins
• Cell Death (drug effects)
• Cell Line
• Cell Line, Tumor
• Dose-Response Relationship, Drug
• Humans
• Kidney (cytology, drug effects)
• Lung (cytology, drug effects)
• Male
• Nuclear Matrix-Associated Proteins (metabolism)
• Pancreatic Neoplasms (drug therapy, metabolism, pathology)
• Peptide Fragments (pharmacology)
• Prostate (cytology, drug effects)
• Prostatic Neoplasms (drug therapy, metabolism, pathology)
• Protein Precursors (pharmacology)