Circulating levels of vascular endothelial growth factor A and its soluble receptor in patients with biopsy-proven nonalcoholic fatty liver disease.

Vascular endothelial growth factor A (VEGF) is a multifunctional cytokine affecting angiogenesis and vascular function. The biological activity of VEGF is modulated by its soluble receptor VEGFR-1 (sVEGFR-1). We explored the associations of VEGF and sVEGFR-1 concentrations with liver histology in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD).
The study was comprised of 99 patients with NAFLD and 75 healthy controls. Serum VEGF and sVEGFR-1 concentrations were measured using commercially available enzyme-linked immunosorbent assays.
Serum VEGF levels did not differ in patients with NAFLD (1882 ± 942 pg/mL) compared with healthy controls (1985 ± 945 pg/mL, p = 0.42). However, compared with healthy subjects, levels of sVEGFR-1 were significantly lower in patients with NAFLD (1.59 ± 0.58 ng/mL vs. 1.16 ± 0.34 ng/mL, respectively, p <0.001). After allowance for potential confounders, serum sVEGFR-1 levels retained their independent significance as a predictor of liver fibrosis in patients with NAFLD (β = -0.19; t = -1.81, p <0.05).
Our results show that patients with biopsy-proven NAFLD have a significant reduction in serum sVEGFR-1 concentrations that predict the degree of liver fibrosis, independent of potential confounders.
AuthorsYusuf Yilmaz, Oya Yonal, Ramazan Kurt, Yesim Ozen Alahdab, Osman Ozdogan, Cigdem Ataizi Celikel, Engin Ulukaya, Nese Imeryuz, Cem Kalayci, Erol Avsar
JournalArchives of medical research (Arch Med Res) Vol. 42 Issue 1 Pg. 38-43 (Jan 2011) ISSN: 1873-5487 [Electronic] United States
PMID21376261 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 IMSS. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factor Receptor-1
  • Adult
  • Biopsy
  • Fatty Liver (blood, pathology)
  • Female
  • Humans
  • Liver (pathology)
  • Male
  • Middle Aged
  • Non-alcoholic Fatty Liver Disease
  • Vascular Endothelial Growth Factor A (blood)
  • Vascular Endothelial Growth Factor Receptor-1 (blood)

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