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[Progress of researches on the allergens Ara h 1, Ara h 2 and Ara h 3 from peanut].

Abstract
Peanut is one of the most popular foods in the world due to its high nutrition; however, it contains multiple seed storage proteins which are identified as allergens and hence are the most common cause of life-threatening, IgE-mediated anaphylaxis among the hypersensitive individuals. Three peanut proteins, Arachis hypogaea allergy 1, 2, 3 (Ara h 1, Ara h 2 and Ara h 3), which have the common biochemical characteristics like resistance to proteases and heat, are considered as the major allergens because they are recognized by serum IgE from a peanut-allergic patient population. The linear IgE-binding epitopes in the allergens lay the foundation of the anaphylaxis in the peanut-allergic individuals. Peanut allergy is often a life-long problem, so many investigators are focusing on decreasing clinical reactivity. In this review, the latest advances in the researches on biochemical characteristics, structure and function of the three major allergens were described and particular attention was given to the immunity properties of the three allergens. The future research directions were also discussed.
AuthorsShengjuan Jiang, Zhengyi Zhou, Yujun Sun, Songhua Wang
JournalSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi (Sheng Wu Yi Xue Gong Cheng Xue Za Zhi) Vol. 27 Issue 6 Pg. 1401-5 (Dec 2010) ISSN: 1001-5515 [Print] China
PMID21375004 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • 2S Albumins, Plant
  • Antigens, Plant
  • Ara h 1 protein, Arachis hypogaea
  • Ara h 2 allergen, Arachis hypogaea
  • Ara h 3 allergen, Arachis hypogea
  • Glycoproteins
  • Membrane Proteins
  • Plant Proteins
  • Immunoglobulin E
  • DNA
Topics
  • 2S Albumins, Plant (chemistry, genetics, immunology)
  • Animals
  • Antigens, Plant (chemistry, genetics, immunology)
  • Arachis (chemistry)
  • DNA (genetics)
  • Glycoproteins (chemistry, genetics, immunology)
  • Humans
  • Immunoglobulin E (genetics)
  • Membrane Proteins
  • Plant Proteins (chemistry, genetics, immunology)

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