[A case of pancreatic acinar cell carcinoma with a giant liver metastasis successfully treated with combination of gemcitabine and peroral S-1].

Abstract

Pancreatic acinar cell carcinoma is rare, and its incidence is less than 1% of all the malignant pancreatic tumors. Little is reported on effectiveness of chemotherapy. We report a 64-year-old male patient with pancreatic acinar cell carcinoma and a giant metastatic liver tumor, which responded to combination chemotherapy with gemcitabine(GEM)and peroral S-1 administration. The patient had upper abdominal pain and hypervascular tumors in liver(15 cm in diameter)and pancreas tail (3 cm in diameter), which were detected by an enhanced abdominal computed tomography(CT)scan, and was admitted for further examination. Abdominal angiography, FDG-positron emission tomography(PET), and liver tumor biopsy led to a diagnosis of pancreatic acinar cell carcinoma in the pancreas tail with liver metastasis. The patient was then treated with combination chemotherapy, which consisted of intravenous infusion of GEM and peroral administration of S-1, and the metastatic liver tumor was markedly reduced(partial response in RECIST). Although the prognosis of patients with unresectable pancreatic acinar cell cancers is generally unfavorable, it is suggested that the GEM/S- 1 combination chemotherapy is effective for these patients' treatment.

• Authors: Toshinori Nishimizu, Masami Minemura, Shinya Kajiura, Yoshiharu Tokimitsu, Yuko Itaya, Hidemoto Yamawaki, Kengo Kawai, Kazuto Tajiri, Yasuhiro Nakayama, Ayumu Hosokawa, Terumi Takahara, Satoshi Yasumura, Shigeki Shimizu, Junya Fukuoka, Shin Ishizawa, Takuro Sawasaki, Akio Yanagisawa, Toshiro Sugiyama
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 2 Pg. 309-12 (Feb 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 21368502 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Deoxycytidine
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Gemcitabine

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biopsy
• Carcinoma, Acinar Cell (drug therapy, pathology)
• Deoxycytidine (administration & dosage, analogs & derivatives, therapeutic use)
• Drug Combinations
• Humans
• Liver Neoplasms (drug therapy, secondary)
• Male
• Middle Aged
• Oxonic Acid (administration & dosage, therapeutic use)
• Tegafur (administration & dosage, therapeutic use)
• Gemcitabine