Antibody persistence and immune memory 4 years post-vaccination with combined hepatitis A and B vaccine in adults aged over 40 years.

Abstract

Persistence of immune response was assessed in adults aged >40 years (N = 596) following primary vaccination with combined hepatitis A/B vaccine or concomitant monovalent hepatitis A and B vaccines. Anti-hepatitis A virus antibody responses persisted for at least 4 years regardless of the vaccine used, with anti-hepatitis B surface antibody responses higher and more sustained in subjects who received the combined hepatitis A/B vaccine. Response rates to an additional dose of the same vaccine(s) used for priming were high.

• Authors: Roman Chlibek, Frank von Sonnenburg, Pierre Van Damme, Jan Smetana, Petr Tichy, Bhavyashree Gunapalaiah, Maarten Leyssen, Jeanne-Marie Jacquet
• Journal: Journal of travel medicine (J Travel Med) 2011 Mar-Apr Vol. 18 Issue 2 Pg. 145-8 ISSN: 1708-8305 [Electronic] England
• PMID: 21366801 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 International Society of Travel Medicine.

Chemical References

• Hepatitis A Antibodies
• Hepatitis A Vaccines
• Hepatitis B Antibodies
• Hepatitis B Vaccines
• Vaccines, Combined

Topics

• Adult
• Female
• Hepatitis A (prevention & control)
• Hepatitis A Antibodies (blood)
• Hepatitis A Vaccines (administration & dosage, immunology)
• Hepatitis B (prevention & control)
• Hepatitis B Antibodies (blood)
• Hepatitis B Vaccines (administration & dosage, immunology)
• Humans
• Immunization, Secondary
• Immunologic Memory
• Male
• Middle Aged
• Vaccines, Combined (immunology)