Abstract | AIMS: MAIN METHODS: KEY FINDINGS: Intrastriatal quinolinic acid (300 nmol) administration significantly altered the body weight, motor coordination, and induced oxidative damage (as indicated by the increase in lipid peroxidation and nitrite concentration) in the striatum as compared to sham group. Besides quinolinic acid (300 nmol) significantly depleted the mitochondrial enzyme complex levels and increased TNF-α, IL-6 and caspase-3 (marker of apoptotic cell death) levels in the striatum. Chronic treatment with celecoxib (15 and 30 mg/kg) significantly attenuated the quinolinic acid-induced behavioral and biochemical alterations, while meloxicam was able to reverse behavioral alterations at higher dose (20 mg/kg) as compared to the quinolinic acid treated group. Chronic treatment with the selective COX-2 inhibitors significantly restored the mitochondrial enzyme complex activities as well as attenuated TNF-α, IL-6 and caspase-3 levels as compared to the quinolinic acid treated group. SIGNIFICANCE:
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Authors | Harikesh Kalonia, Anil Kumar |
Journal | Life sciences
(Life Sci)
Vol. 88
Issue 17-18
Pg. 784-91
(Apr 25 2011)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 21362433
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011. Published by Elsevier Inc. |
Chemical References |
- Cyclooxygenase Inhibitors
- Interleukin-6
- Pyrazoles
- Sulfonamides
- Thiazines
- Thiazoles
- Tumor Necrosis Factor-alpha
- Caspase 3
- Quinolinic Acid
- Celecoxib
- Meloxicam
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Topics |
- Animals
- Brain
(drug effects)
- Caspase 3
(blood)
- Celecoxib
- Cyclooxygenase Inhibitors
(pharmacology)
- Dose-Response Relationship, Drug
- Huntington Disease
(chemically induced)
- Inflammation
(drug therapy)
- Interleukin-6
(blood)
- Lipid Peroxidation
(drug effects)
- Locomotion
(drug effects)
- Male
- Meloxicam
- Mitochondria
(drug effects)
- Oxidative Stress
(drug effects)
- Pyrazoles
(pharmacology)
- Quinolinic Acid
(antagonists & inhibitors, pharmacology)
- Rats
- Rats, Wistar
- Sulfonamides
(pharmacology)
- Thiazines
(pharmacology)
- Thiazoles
(pharmacology)
- Tumor Necrosis Factor-alpha
(blood)
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