Development of cell-mediated immunity to Marek's disease tumor cells in chickens inoculated with Marek's disease vaccines.
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| Abstract |
Chickens inoculated with herpesvirus of turkeys or with apathogenic or attenuated vaccine strains of Marek's disease virus (MDV) developed a T-cell-mediated immune response to Marek's disease (MD) tumor cells. This immune response was detected in a 4-hour 51Cr-release assay in which effector cells obtained from spleens of vaccinated chickens were reacted with 51Cr-labeled target cells of an MD lymphoblastoid cell line (MSB-1). The cytotoxic effector cells generated by the vaccine viruses had characteristics similar to those noted previously for anti-MSB-1 effector cells generated by MDV. The immune response was specific to MSB-1 cells, because another target cell line (TLT) antigenically unrelated to MSB-1 cells was not lysed by the effector cells nor did the unrelated target cells inhibit the cytotoxicity of effector cells against MSB-1 target in a cold-target inhibition assay. Because MSB-1 cells contain MD tumor-associated surface antigen, we postulated that the immune response detected in the vaccinated chickens may be directed against this antigen and that the antitumor antigen immunity may play a role in the mechanism of vaccine protection against lymphoma development by pathogenic MDV.
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| Authors | J M Sharma, R L Witter, B D Coulson |
| Journal | Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 61 Issue 5 Pg. 1273-80 (Nov 1978) ISSN: 0027-8874 [Print] United States |
| PMID | 213610 (Publication Type: Journal Article) |
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