Abstract |
This retrospective study was performed to investigate the diagnostic efficacy of the chemiluminometric ACTH-measurement to differentiate between pituitary and adrenal dependent hyperadrenocorticism (HAC) in dogs. 49 dogs with pituitary HAC, 10 dogs with adrenal HAC and 1 dog with a combination of both pathologies were included. Dogs with HAC like symptoms, where HAC had been ruled out, served as controls (n = 18). All dogs with adrenal HAC, as well as 9 dogs with pituitary HAC had an ACTH concentration below the detection limit of 2.2 pmol/l (10 pg/dl) plasma. Using 2.2 pmol/l as a cut-off the sensitivity and specificity to diagnose pituitary HAC was 0.82 (95 % CI 0.686 - 0.914) and 1 (95 % CI 0.692 - 1), respectively. With the help of the chemiluminometric assay, a correct classification was possible in 85 % of patients with HAC. As an ACTH-concentration below the detection limit was found in dogs with adrenal as well as pituitary HAC, additional discriminatory tests are necessary in these cases.
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Authors | F Zeugswetter, M Pagitz, K Hittmair, I Schwendenwein |
Journal | Schweizer Archiv fur Tierheilkunde
(Schweiz Arch Tierheilkd)
Vol. 153
Issue 3
Pg. 111-6
(Mar 2011)
ISSN: 0036-7281 [Print] Switzerland |
Vernacular Title | Klinische Anwendung einer chemiluminometrischen ACTH-Bestimmung beim caninen Hyperadrenokortizismus. |
PMID | 21360448
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Adrenocorticotropic Hormone
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Topics |
- Adrenocortical Hyperfunction
(blood, diagnosis, veterinary)
- Adrenocorticotropic Hormone
(blood)
- Animals
- Diagnosis, Differential
- Dog Diseases
(blood, diagnosis)
- Dogs
- Female
- Luminescent Measurements
(standards, veterinary)
- Male
- Pituitary ACTH Hypersecretion
(blood, diagnosis, veterinary)
- Retrospective Studies
- Sensitivity and Specificity
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