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[Diagnostic efficacy of plasma ACTH-measurement by a chemiluminometric assay in canine hyperadrenocorticism].

Abstract
This retrospective study was performed to investigate the diagnostic efficacy of the chemiluminometric ACTH-measurement to differentiate between pituitary and adrenal dependent hyperadrenocorticism (HAC) in dogs. 49 dogs with pituitary HAC, 10 dogs with adrenal HAC and 1 dog with a combination of both pathologies were included. Dogs with HAC like symptoms, where HAC had been ruled out, served as controls (n = 18). All dogs with adrenal HAC, as well as 9 dogs with pituitary HAC had an ACTH concentration below the detection limit of 2.2 pmol/l (10 pg/dl) plasma. Using 2.2 pmol/l as a cut-off the sensitivity and specificity to diagnose pituitary HAC was 0.82 (95 % CI 0.686 - 0.914) and 1 (95 % CI 0.692 - 1), respectively. With the help of the chemiluminometric assay, a correct classification was possible in 85 % of patients with HAC. As an ACTH-concentration below the detection limit was found in dogs with adrenal as well as pituitary HAC, additional discriminatory tests are necessary in these cases.
AuthorsF Zeugswetter, M Pagitz, K Hittmair, I Schwendenwein
JournalSchweizer Archiv fur Tierheilkunde (Schweiz Arch Tierheilkd) Vol. 153 Issue 3 Pg. 111-6 (Mar 2011) ISSN: 0036-7281 [Print] Switzerland
Vernacular TitleKlinische Anwendung einer chemiluminometrischen ACTH-Bestimmung beim caninen Hyperadrenokortizismus.
PMID21360448 (Publication Type: Evaluation Study, Journal Article)
Chemical References
  • Adrenocorticotropic Hormone
Topics
  • Adrenocortical Hyperfunction (blood, diagnosis, veterinary)
  • Adrenocorticotropic Hormone (blood)
  • Animals
  • Diagnosis, Differential
  • Dog Diseases (blood, diagnosis)
  • Dogs
  • Female
  • Luminescent Measurements (standards, veterinary)
  • Male
  • Pituitary ACTH Hypersecretion (blood, diagnosis, veterinary)
  • Retrospective Studies
  • Sensitivity and Specificity

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