Abstract | BACKGROUND: METHODS: RESULTS: The number of labeled RGCs and the expression of BDNF and GDNF mRNA obviously increased, and pathological injury was significantly ameliorated in the transplantation group compared to the model group (P < 0.05). CONCLUSIONS: Via intravitreal transplantation, the hUCBSCs resulted in a significant increase in the survival of the RGCs, and improved pathological changes in the rat retina, following TON. The protective mechanism is correlated with the continuous secretion of BDNF and GDNF in vivo of retina in optic nerve injury rats by the transplanted hUCBSCs.
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Authors | Tantai Zhao, Yunqin Li, Luosheng Tang, Yuehua Li, Fang Fan, Bing Jiang |
Journal | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
(Graefes Arch Clin Exp Ophthalmol)
Vol. 249
Issue 7
Pg. 1021-8
(Jul 2011)
ISSN: 1435-702X [Electronic] Germany |
PMID | 21360302
(Publication Type: Journal Article)
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Chemical References |
- Brain-Derived Neurotrophic Factor
- Glial Cell Line-Derived Neurotrophic Factor
- RNA, Messenger
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Topics |
- Animals
- Brain-Derived Neurotrophic Factor
(genetics)
- Cell Count
- Cord Blood Stem Cell Transplantation
- Cytoprotection
- Disease Models, Animal
- Female
- Fetal Blood
(cytology)
- Glial Cell Line-Derived Neurotrophic Factor
(genetics)
- Humans
- Male
- Nerve Crush
- Optic Nerve Injuries
(genetics, pathology, prevention & control)
- RNA, Messenger
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Retinal Ganglion Cells
(metabolism, pathology)
- Reverse Transcriptase Polymerase Chain Reaction
- Vitreous Body
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