Retinoid X receptor γ up-regulation is correlated with dedifferentiation of tumor cells and lymph node metastasis in papillary thyroid carcinoma.

Abstract

The expression of retinoid X receptor γ (RXRγ) and the clinicopathological parameters of total 69 patients with papillary thyroid carcinoma (PTC) larger than 1 cm were examined. The PTCs were classified into two groups according to the presence of loss of cellular polarity/cohesiveness (LOP/C). The expression of RXRγ mRNA was examined by reverse transcriptase polymerase chain reaction and quantitative real-time PCR. The RXRγ mRNA up-regulation was found to be positively correlated with extrathyroid invasion (r = 0.293, P = 0.019), advanced tumor stage (r = 0.318, P = 0.016) and lymph node metastasis (LNM) (r = 0.338, P = 0.005), as well as LOP/C (r = 0.345, P = 0.004), which was proposed as a histological characteristic of poor cellular differentiation. The RXRγ mRNA expression, as well as extrathyroid invasion, LOP/C and advanced tumor stage, was further confirmed to be one of the independent predictive factors (Odds ratio: 6.545; 95% confidence interval: 1.575-27.208) of LNM using multivariate analysis. These results suggest that RXRγ may play a role in the dedifferentiation and metastasis of PTC.

• Authors: Zhiyan Liu, Gengyin Zhou, Misa Nakamura, Yanhua Bai, Yaqiong Li, Takashi Ozaki, Ichiro Mori, Akira Miyauchi, Kennichi Kakudo
• Journal: Pathology international (Pathol Int) Vol. 61 Issue 3 Pg. 109-15 (Mar 2011) ISSN: 1440-1827 [Electronic] Australia
• PMID: 21355951 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.

Chemical References

• RNA, Messenger
• Retinoid X Receptor gamma

Topics

• Adenocarcinoma, Papillary (genetics, metabolism, secondary)
• Cell Dedifferentiation (genetics)
• Cell Transformation, Neoplastic
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Lymph Nodes (metabolism, pathology)
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Invasiveness
• RNA, Messenger (metabolism)
• Retinoid X Receptor gamma (genetics, metabolism)
• Reverse Transcriptase Polymerase Chain Reaction
• Thyroid Neoplasms (genetics, metabolism, pathology)
• Thyroidectomy
• Up-Regulation (genetics)