Abstract | OBJECTIVE: METHOD: 36 SD rats were divided into 3 groups randomly, sham-operated group, model group, Xuefu Zhuyu decoction group. The model of MI/RI of the myocardium was reproduced by ligation of left descending artery for 30 min followed by releasing the ligation for 2 hours in rats. Serum contents of LDH-L, CK were measured, the levels of serum IL-1beta, IL-6 and IL-10 were measured and myocardial ultrastructure at the ischemia region was observed under the transmission electron microscope after myocardial reperfusion injury. RESULT: Compared with model group, IL-1beta, IL-6 and IL-10 levels were lower, myocardial ultrastructural changes were improved in Xuefu Zhuyu decoction group (P < 0.01), however, serum contents of LDH-L and CK no significant difference were found among the model group and Xuefu Zhuyu decoction group. CONCLUSION:
Xuefu Zhuyu decoction can protect myocardium from MI/RI, the mechanism of action was related to inhibiting inflammatory reaction and reducing arrhythmia and the injury of the myocardial ultrastructure.
|
Authors | Danli Tang, Zhaihua Liu, Huamin Zhang, Mingjie Sun, Yu Sui |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 35
Issue 22
Pg. 3077-9
(Nov 2010)
ISSN: 1001-5302 [Print] China |
PMID | 21355287
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Drugs, Chinese Herbal
- Interleukin-6
- Protective Agents
- Xue-Fu-Zhu-Yu decoction
- Interleukin-10
|
Topics |
- Animals
- Disease Models, Animal
- Drugs, Chinese Herbal
(therapeutic use)
- Humans
- Interleukin-10
(immunology)
- Interleukin-6
(immunology)
- Male
- Myocardial Reperfusion Injury
(drug therapy, immunology, prevention & control)
- Protective Agents
(therapeutic use)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
|