[Expression of RUNX3 protein in hepatic cell carcinoma and its clinicopathological implications].

Abstract

OBJECTIVE:

To investigate the expression of RUNX3 protein in hepatic cell carcinoma (HCC) and its relationship with the clinicopathological factors of HCC.

METHODS:

Immunohistochemistry was performed to detect the expression of RUNX3 protein in HCC and the surrounding normal tissues, and the relation of RUNX3 with the clinicopathological factors of HCC was analyzed.

RESULTS:

The positivity rate of RUNX3 protein expression was 49.02% (25/51) in HCC tissues, significantly lower than that in the surrounding normal tissues [82.35% (42/51), Χ(2)=12.5706, P<0.01). RUNX3 protein expression varied significantly with such pathological factors as the differentiation degree, cancer-associated thrombosis in the portal vein and intrahepatic metastasis (P<0.05), but not with tumor diameter, location, tumoral hemorrhage, necrosis or histotypes of the tumor (P>0.05).

CONCLUSION:

RUNX3 protein expression is lowered in HCC as compared with that in the surrounding normal tissue, suggesting an important role of RUNX3 in the tumorigenesis and development of HCC and the possible identity of RUNX3 gene as an anti-oncogene of HCC.

• Authors: Yan-hui Lu, Rui-dan Zheng, Jie Chen, Bi-fen Chen, Jian-guo Li, Zhi-chuan Lin
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 31 Issue 2 Pg. 329-32 (Feb 2011) ISSN: 1673-4254 [Print] China
• PMID: 21354923 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Core Binding Factor Alpha 3 Subunit
• Runx3 protein, human
• Tumor Suppressor Proteins

Topics

• Carcinoma, Hepatocellular (genetics, metabolism, pathology)
• Core Binding Factor Alpha 3 Subunit (genetics, metabolism)
• Down-Regulation
• Female
• Genes, Tumor Suppressor
• Humans
• Liver Neoplasms (genetics, metabolism, pathology)
• Male
• Tumor Suppressor Proteins (genetics, metabolism)