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Assay of two 10% (w/v) fipronil spot-on formulations against feline infestations with Ctenocephalides felis.

Abstract
A new fipronil-based spot-on formulation was evaluated against experimental flea infestations in cats in two studies. In both studies, eight cats served as negative controls (groups 1 and 4); on day 0, eight cats were treated with a 10% w/v fipronil-based spot-on solution (Effipro Spot-on, 0.5ml per cat, groups 2 and 5) and eight cats served as positive controls (Frontline Spot-on, 0.5ml per cat, groups 3 and 6). Each cat was infested on day - 1 with 50 fleas (study 1) and weekly (day 7-day 56) with 100 fleas (study 2). Geometric mean flea counts obtained 48h after the treatment or each re-infestation were reduced by 99.0 and 98.3% in groups 2 and 3, respectively, on day 2, compared to the negative control group. Cats were protected from re-infestations with an efficacy >99% for 58 days in group 5 and for 37 days in group 6.
AuthorsMarie-Christine Cadiergues, Stéphane G Bonneau, Josephus J Fourier
JournalJournal of feline medicine and surgery (J Feline Med Surg) Vol. 13 Issue 4 Pg. 304-8 (Apr 2011) ISSN: 1532-2750 [Electronic] England
PMID21354841 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Insecticides
  • Pyrazoles
  • fipronil
Topics
  • Animals
  • Cat Diseases (drug therapy)
  • Cats
  • Ctenocephalides (drug effects)
  • Female
  • Flea Infestations (drug therapy, veterinary)
  • Insecticides (therapeutic use)
  • Male
  • Pyrazoles (therapeutic use)
  • Treatment Outcome

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