Antiplatelet effects of Cyperus rotundus and its component (+)-nootkatone.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Cyperus rotundus, a well-known oriental traditional medicine, has been reported to exhibit wide spectrum activity in biological systems including the circulatory system, however, little information is available on its antiplatelet activity. This study was undertaken to investigate the antiplatelet effects of Cyperus rotundus EtOH extract (CRE) and its constituent compounds.

MATERIALS AND METHODS:

The antiplatelet activities of CRE and its eight constituent compounds were evaluated by examining their effects on rat platelet aggregations in vitro and ex vivo, and on mice tail bleeding times.

RESULTS:

During the in vitro platelet aggregation study, CRE showed significant and concentration-dependent inhibitory effects on collagen-, thrombin-, and/or AA-induced platelet aggregation. Of its eight components, (+)-nootkatone was found to have the most potent inhibitory effect on collagen-, thrombin-, and AA-induced platelet aggregation. In addition, CRE- and (+)-nootkatone-treated mice exhibited significantly prolonged bleeding times. Furthermore, (+)-nootkatone had a significant inhibitory effect on rat platelet aggregation ex vivo.

CONCLUSIONS:

This study demonstrates the antiplatelet effects of CRE and its active component (+)-nootkatone, and suggests that these agents might be of therapeutic benefit for the prevention of platelet-associated cardiovascular diseases.

• Authors: Eun Ji Seo, Dong-Ung Lee, Jong Hwan Kwak, Sun-Mee Lee, Yeong Shik Kim, Yi-Sook Jung
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 135 Issue 1 Pg. 48-54 (Apr 26 2011) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 21354294 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Plant Extracts
• Platelet Aggregation Inhibitors
• Polycyclic Sesquiterpenes
• Sesquiterpenes
• Arachidonic Acid
• Collagen
• Thrombin
• nootkatone

Topics

• Animals
• Arachidonic Acid
• Bleeding Time
• Collagen
• Cyperus (chemistry)
• Mice
• Mice, Inbred ICR
• Plant Extracts (pharmacology)
• Platelet Aggregation (drug effects)
• Platelet Aggregation Inhibitors (pharmacology)
• Polycyclic Sesquiterpenes
• Rats
• Rats, Sprague-Dawley
• Sesquiterpenes (pharmacology)
• Thrombin