Abstract | BACKGROUND & AIMS: Oxidative stress is implicated in the pathogenesis of pancreatitis, but clinical trials of antioxidants have produced conflicting results. We examined the role of intracellular reactive oxygen species (ROS) in pancreatic acinar cell injury. METHODS: RESULTS: CONCLUSIONS: Increases in [ROS]M and [ROS]I during bile acid injury of pancreatic acinar cells promote apoptosis but not necrosis. These results indicate that alternative strategies to antioxidants are required for oxidative stress in acute pancreatitis.
|
Authors | David M Booth, John A Murphy, Rajarshi Mukherjee, Muhammad Awais, John P Neoptolemos, Oleg V Gerasimenko, Alexei V Tepikin, Ole H Petersen, Robert Sutton, David N Criddle |
Journal | Gastroenterology
(Gastroenterology)
Vol. 140
Issue 7
Pg. 2116-25
(Jun 2011)
ISSN: 1528-0012 [Electronic] United States |
PMID | 21354148
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antioxidants
- Chlorides
- Oxidants
- Reactive Oxygen Species
- taurolithocholic acid 3-sulfate
- Taurolithocholic Acid
- NADP
- Adenosine Triphosphate
- Calcium
|
Topics |
- Adenosine Triphosphate
(metabolism)
- Animals
- Antioxidants
(pharmacology)
- Apoptosis
(drug effects)
- Calcium
(metabolism)
- Chlorides
(metabolism)
- Cytoprotection
- Humans
- Membrane Potentials
- Mice
- Microscopy, Confocal
- Mitochondria
(metabolism, pathology)
- NADP
(metabolism)
- Necrosis
- Oxidants
(pharmacology)
- Oxidative Stress
(drug effects)
- Pancreas, Exocrine
(drug effects, metabolism, pathology)
- Pancreatitis
(drug therapy, metabolism, pathology)
- Patch-Clamp Techniques
- Reactive Oxygen Species
(metabolism)
- Signal Transduction
- Taurolithocholic Acid
(analogs & derivatives, metabolism)
- Time Factors
|