We report a case of recurrent
choroidal neovascularization (CNV) in an eye with chorioretinal
coloboma. A 36-year-old woman presented complaining of decreased visual acuity (VA) in her left eye. Best corrected visual acuity (BCVA) was 20/200 and iris
coloboma was observed. Funduscopy and
fluorescein angiography (FA) showed CNV in the superior extrafoveal region with chorioretinal
coloboma reaching just inferior to the optic disc. No other cause for CNV was observed except for the chorioretinal
coloboma. BCVA improved to 20/30 after
laser photocoagulation. She revisited our clinic for deteriorating VA (20/400) in the same eye 3 years
after treatment. Funduscopy and FA demonstrated recurrent CNV with subfoveal
hemorrhage.
Photodynamic therapy (
PDT) was followed by three consecutive intravitreal
bevacizumab injections (IVB) for the subfoveally-located CNV. However, the CNV persisted with the appearance of a fresh subretinal
hemorrhage. Additional
PDT was combined with IVB on the same day 6 months after the initial
PDT. The CNV regressed 3 months
after treatment and has not recurred as of 8 months after the last treatment. The patient's BCVA improved to 20/60. This case suggests that
PDT combined with IVB can be an alternative treatment for the management of recurrent CNV after
laser photocoagulation in eyes with chorioretinal
coloboma.