[Efficacy and tolerability of pantogam activ in patients with partial epilepsy].

Abstract

Randomized double-blind, placebo-controlled study to determine efficacy and tolerability of pantogam activ as an add-on drug in patients with partial epilepsy was conducted. 20 patients received pantogam activ, 20 patients - placebo. Good tolerability and no advers event were detected in the dose of 1800 mg/d. The reduction in the frequency of epileptic seizures was achieved in 72,1% in the group receiving pantogam activ and in 16,7% in the group placebo. Significant improvement in long-term memory and manifestations of anxiety were found in patients using pantogam activ. Quality of life in scale QOLIE-31 improved after taking pantogam and did not change after placebo.

• Authors: I E Poverennova, A V Iakunina, V A Kalinin, N N Savel'eva
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 111 Issue 2 Pg. 54-9 ( 2011) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 21350425 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Nootropic Agents
• Placebos
• pantogab
• Pantothenic Acid
• gamma-Aminobutyric Acid

Topics

• Adult
• Epilepsies, Partial (drug therapy, physiopathology)
• Female
• Humans
• Male
• Middle Aged
• Nootropic Agents (therapeutic use)
• Pantothenic Acid (adverse effects, analogs & derivatives, therapeutic use)
• Placebos (administration & dosage, therapeutic use)
• Quality of Life
• Surveys and Questionnaires
• Treatment Outcome
• Young Adult
• gamma-Aminobutyric Acid (adverse effects, analogs & derivatives, therapeutic use)