Abstract | BACKGROUND: PATIENTS AND METHODS: 13 adult patients with refractory chronic ITP were treated with the new TM. 10 patients were only treated with eltrombopag, 2 were initially treated with eltrombopag and subsequently switched to romiplostim, and 1 patient was only treated with romiplostim. RESULTS: Ten patients responded to eltrombopag, and 4 of these patients experienced a transient loss of response following infection. Two patients developed bleeding symptoms, with 1 of these patients requiring platelet transfusion. All 3 patients treated with romiplostim responded, and 1 of these patients experienced also a transient loss of response following infections. CONCLUSIONS: Patients receiving treatment with TM may experience adverse platelet count fluctuations during infections.
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Authors | Oliver Meyer, Abdulgabar Salama |
Journal | Onkologie
(Onkologie)
Vol. 34
Issue 1-2
Pg. 10-3
( 2011)
ISSN: 1423-0240 [Electronic] Switzerland |
PMID | 21346379
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 S. Karger AG, Basel. |
Chemical References |
- Benzoates
- Hydrazines
- Pyrazoles
- Receptors, Fc
- Receptors, Thrombopoietin
- Recombinant Fusion Proteins
- Thrombopoietin
- romiplostim
- eltrombopag
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Benzoates
(adverse effects, therapeutic use)
- Chronic Disease
- Female
- Humans
- Hydrazines
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Platelet Activation
(drug effects)
- Purpura, Thrombocytopenic, Idiopathic
(drug therapy)
- Pyrazoles
(adverse effects, therapeutic use)
- Receptors, Fc
(therapeutic use)
- Receptors, Thrombopoietin
(agonists)
- Recombinant Fusion Proteins
(adverse effects, therapeutic use)
- Thrombopoietin
(adverse effects, therapeutic use)
- Treatment Outcome
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