Abstract |
Patients with rheumatoid arthritis (RA) and osteoarthritis (OA) consume 'natural health products' (NHPs) whose therapeutic efficacy, toxicity and mechanisms of action are poorly understood. In a previous issue of Arthritis Research and Therapy, Haqqi and colleagues characterized IL-1-activated mitogen-activated protein kinase kinase 3 (MKK3) and p38-mitogen-activated protein kinase (MAPK) isoforms in human OA chondrocytes. The cartilageprotective mechanisms of pomegranate extract involve diminishing MKK3-activated p38α, JNK, NF-κB and Runx2 pathways, which regulate inflammatory proteins and cartilage-destroying proteases. Epigallocatechin- 3-gallate, resveratrol, curcumin and other NHP active ingredients suppress multiple inflammatory and catabolic molecular mediators of arthritis. Non-toxicity, reduced severity and incidence of arthritis in animal models warrant testing NHP active ingredients for preventing human OA and RA.
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Authors | Sarah Khalifé, Muhammad Zafarullah |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 13
Issue 1
Pg. 102
(Feb 03 2011)
ISSN: 1478-6362 [Electronic] England |
PMID | 21345249
(Publication Type: Editorial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Antioxidants
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Antioxidants
(pharmacology)
- Arthritis
(drug therapy)
- Complementary Therapies
(methods)
- Food, Organic
- Humans
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