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Synthesis of calophyllolide analogue and its preliminary anti-inflammatory activity.

Abstract
A new pyranocoumarin as an analogue of calophyllolide, compound 6, is firstly prepared and reported to have potent anti-inflammatory activity on carrageenin-induced edema in rats.
AuthorsTao Ma, Lin Wang, Gui-fang Cheng, Gang Liu
JournalYao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 45 Issue 10 Pg. 1265-9 (Oct 2010) ISSN: 0513-4870 [Print] China
PMID21344845 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • (2,2-dimethyl-8-oxo-10-phenyl-pyrano(2,3f)chromen-5-yl)(E)-but-2-enoate
  • Anti-Inflammatory Agents, Non-Steroidal
  • Coumarins
  • calophyllolid
  • Carrageenan
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (chemical synthesis, chemistry, therapeutic use)
  • Carrageenan
  • Coumarins (chemical synthesis, chemistry, pharmacology, therapeutic use)
  • Edema (chemically induced, drug therapy)
  • Male
  • Molecular Structure
  • Rats
  • Rats, Wistar

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