Accuracy and outcomes of screening mammography in women with a personal history of early-stage breast cancer.

Abstract

CONTEXT:

Women with a personal history of breast cancer (PHBC) are at risk of developing another breast cancer and are recommended for screening mammography. Few high-quality data exist on screening performance in PHBC women.

OBJECTIVE:

To examine the accuracy and outcomes of mammography screening in PHBC women relative to screening of similar women without PHBC.

DESIGN AND SETTING:

Cohort of PHBC women, mammogram matched to non-PHBC women, screened through facilities (1996-2007) affiliated with the Breast Cancer Surveillance Consortium.

PARTICIPANTS:

There were 58,870 screening mammograms in 19,078 women with a history of early-stage (in situ or stage I-II invasive) breast cancer and 58,870 matched (breast density, age group, mammography year, and registry) screening mammograms in 55,315 non-PHBC women.

MAIN OUTCOME MEASURES:

Mammography accuracy based on final assessment, cancer detection rate, interval cancer rate, and stage at diagnosis.

RESULTS:

Within 1 year after screening, 655 cancers were observed in PHBC women (499 invasive, 156 in situ) and 342 cancers (285 invasive, 57 in situ) in non-PHBC women. Screening accuracy and outcomes in PHBC relative to non-PHBC women were cancer rates of 10.5 per 1000 screens (95% CI, 9.7-11.3) vs 5.8 per 1000 screens (95% CI, 5.2-6.4), cancer detection rate of 6.8 per 1000 screens (95% CI, 6.2-7.5) vs 4.4 per 1000 screens (95% CI, 3.9-5.0), interval cancer rate of 3.6 per 1000 screens (95% CI, 3.2-4.1) vs 1.4 per 1000 screens (95% CI, 1.1-1.7), sensitivity 65.4% (95% CI, 61.5%-69.0%) vs 76.5% (95% CI, 71.7%-80.7%), specificity 98.3% (95% CI, 98.2%-98.4%) vs 99.0% (95% CI, 98.9%-99.1%), abnormal mammogram results in 2.3% (95% CI, 2.2%-2.5%) vs 1.4% (95% CI, 1.3%-1.5%) (all comparisons P < .001). Screening sensitivity in PHBC women was higher for detection of in situ cancer (78.7%; 95% CI, 71.4%-84.5%) than invasive cancer (61.1%; 95% CI, 56.6%-65.4%), P < .001; lower in the initial 5 years (60.2%; 95% CI, 54.7%-65.5%) than after 5 years from first cancer (70.8%; 95% CI, 65.4%-75.6%), P = .006; and was similar for detection of ipsilateral cancer (66.3%; 95% CI, 60.3%-71.8%) and contralateral cancer (66.1%; 95% CI, 60.9%-70.9%), P = .96. Screen-detected and interval cancers in women with and without PHBC were predominantly early stage.

CONCLUSION:

Mammography screening in PHBC women detects early-stage second breast cancers but has lower sensitivity and higher interval cancer rate, despite more evaluation and higher underlying cancer rate, relative to that in non-PHBC women.

• Authors: Nehmat Houssami, Linn A Abraham, Diana L Miglioretti, Edward A Sickles, Karla Kerlikowske, Diana S M Buist, Berta M Geller, Hyman B Muss, Les Irwig
• Journal: JAMA (JAMA) Vol. 305 Issue 8 Pg. 790-9 (Feb 23 2011) ISSN: 1538-3598 [Electronic] United States
• PMID: 21343578 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Aged
• Aged, 80 and over
• Breast Neoplasms (diagnostic imaging)
• Case-Control Studies
• Cohort Studies
• Female
• Humans
• Mammography (standards)
• Mass Screening (standards)
• Middle Aged
• Neoplasm Staging
• Neoplasms, Second Primary (diagnostic imaging)
• Outcome Assessment, Health Care
• Sensitivity and Specificity