Abstract |
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) has been identified as a major receptor for oxidized low-density lipoprotein ( ox-LDL) in endothelial cells, monocytes, platelets, cardiomyocytes, and vascular smooth muscle cells. Its expression is minimal under physiological conditions but can be induced under pathological conditions. The upregulation of LOX-1 by ox-LDL appears to be important for physiologic processes, such as endothelial cell proliferation, apoptosis, and endothelium remodeling. Pathophysiologic effects of ox-LDL in atherogenesis have also been firmly established, including endothelial cell dysfunction, smooth muscle cell growth and migration, monocyte transformation into macrophages, and finally platelet aggregation-seen in atherogenesis. Recent studies show a positive correlation between increased serum ox-LDL levels and an increased risk of colon, breast, and ovarian cancer. As in atherosclerosis, ox-LDL and its receptor LOX-1 activate the inflammatory pathway through nuclear factor-kappa B, leading to cell transformation. LOX-1 is important for maintaining the transformed state in developmentally diverse cancer cell lines and for tumor growth, suggesting a molecular connection between atherogenesis and tumorigenesis.
|
Authors | Jingjun Lu, Sona Mitra, Xianwei Wang, Magomed Khaidakov, Jawahar L Mehta |
Journal | Antioxidants & redox signaling
(Antioxid Redox Signal)
Vol. 15
Issue 8
Pg. 2301-33
(Oct 15 2011)
ISSN: 1557-7716 [Electronic] United States |
PMID | 21338316
(Publication Type: Journal Article, Review)
|
Chemical References |
- Scavenger Receptors, Class E
|
Topics |
- Animals
- Atherosclerosis
(genetics, metabolism)
- Cell Transformation, Neoplastic
(genetics, metabolism)
- Humans
- Oxidative Stress
(genetics, physiology)
- Scavenger Receptors, Class E
(genetics, metabolism)
|