Glyceollin, a soybean phytoalexin with medicinal properties.

Abstract

This review covers the biosynthesis of glyceollin and its biological activities including antiproliferative/antitumor action (toward B16 melanoma cells, LNCaP prostate cancer cells, and BG-1 ovarian cancer cells), anti-estrogenic action (through estrogen receptors α- and β-), antibacterial action (toward Erwinia carotovora, Escherichia coli, Bradyrhizobium japonicum, Sinorhizobium fredii ), antinematode activity, and antifungal activity (toward Fusarium solani, Phakospora pachyrhizi, Diaporthe phaseolorum, Macrophomina phaseolina, Sclerotina sclerotiorum, Phytophthora sojae, Cercospora sojina, Phialophora gregata, and Rhizoctonia solani). Other activities include insulinotropic action and attenuation of vascular contractions in rat aorta.

• Authors: Tzi Bun Ng, Xiu Juan Ye, Jack Ho Wong, Evandro Fei Fang, Yau Sang Chan, Wenliang Pan, Xiu Yun Ye, Stephen Cho Wing Sze, Kalin Yanbo Zhang, Fang Liu, He Xiang Wang
• Journal: Applied microbiology and biotechnology (Appl Microbiol Biotechnol) Vol. 90 Issue 1 Pg. 59-68 (Apr 2011) ISSN: 1432-0614 [Electronic] Germany
• PMID: 21336922 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anti-Infective Agents
• Antineoplastic Agents
• Pterocarpans
• Sesquiterpenes
• glyceollin
• Phytoalexins

Topics

• Animals
• Anti-Infective Agents (metabolism, pharmacology)
• Antineoplastic Agents (metabolism, pharmacology)
• Drug Therapy
• Humans
• Pterocarpans (biosynthesis, pharmacology)
• Sesquiterpenes (metabolism, pharmacology)
• Soybeans (chemistry, metabolism)
• Phytoalexins