CT portography with gastric variceal volume measurements in the evaluation of endoscopic therapeutic efficacy of tissue adhesive injection into gastric varices: a pilot study.

N-butyl-2-cyanoacrylate (NBCA) injection is used for treating gastric varices (GV). Determining the degree of obliteration of GV is not readily evident at endoscopy.
The aim of this study was to evaluate CT portography with gastric variceal volume calculations to assess endoscopic therapeutic efficacy of NBCA injection.
The study design is a retrospective series pilot study. The setting is a single, tertiary care academic medical center. Ten patients underwent esophagogastroduodenoscopy (EGD) with NBCA injection of GV and had biphasic CT scans performed before and after injection therapy. Based on portal venous images, 3D reconstruction and semi-automated volume calculations of GV were performed. Pre and post injection GV volume calculations were compared.
The mean pre-procedure GV volume was 89.84 cm3. Eight patients had significant improvement in GV volume from pre-treatment versus post-treatment (95.65 cm3 vs. 49.65 cm3, P-value 0.04). Pre-procedure GV volume was not significantly different in patients treated for active hemorrhage versus no hemorrhage (101.66 cm3 vs. 72.11 cm3, P-value 0.33). Two patients had a subsequent GV hemorrhage after NBCA injection. The mean residual GV volume in these patients versus those that did not re-bleed was significantly more (127.77 cm3 vs. 38.00 cm3, P-value 0.005).
CT portography with measurement of GV volume is a potentially useful tool in determining the therapeutic efficacy NBCA injection of GV. Patients with higher residual GV volumes are at increased risk of hemorrhage and may benefit from repeat injection to reach ideal GV volumes.
AuthorsJohn P Rice, Meghan Lubner, Andrew Taylor, Bret J Spier, Adnan Said, Michael R Lucey, Alexandru Musat, Mark Reichelderfer, Patrick R Pfau, Deepak V Gopal
JournalDigestive diseases and sciences (Dig Dis Sci) Vol. 56 Issue 8 Pg. 2466-72 (Aug 2011) ISSN: 1573-2568 [Electronic] United States
PMID21336602 (Publication Type: Evaluation Studies, Journal Article)
Chemical References
  • Tissue Adhesives
  • Enbucrilate
  • Adult
  • Aged
  • Enbucrilate (administration & dosage, adverse effects)
  • Esophageal and Gastric Varices (drug therapy, pathology, radiography)
  • Female
  • Gastrointestinal Hemorrhage (etiology)
  • Gastroscopy
  • Humans
  • Injections (methods)
  • Male
  • Middle Aged
  • Pilot Projects
  • Portography (methods)
  • Retrospective Studies
  • Tissue Adhesives (administration & dosage, adverse effects)
  • Tomography, X-Ray Computed (methods)
  • Treatment Outcome
  • Young Adult

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