Abstract | BACKGROUND: METHODS: From December 2002 to May 2004, 395 consecutive patients with HCC who underwent curative partial hepatectomy were included in the study. The tumor characteristics and clinical outcomes of patients with positive preoperative and postoperative AFP-L3 were compared with those with negative results. RESULTS: A high ratio of AFP-L3 to total AFP was an indicator of pathologic aggressiveness. Patients with positive preoperative AFP-L3 had significantly earlier recurrence (median time to recurrence 22.0 ± 2.4 months vs 45.0 ± 6.9 months, P < .001) when compared with those with negative preoperative results. Significantly more patients with continuously positive or negative-turn-positive AFP-L3 results after surgery developed recurrence, particularly distant metastases, when compared with patients with continuously negative AFP-L3 results. The overall and disease-free survivals were significantly shorter in the positive than the negative preoperative AFP-L3 group. The overall and disease-free survivals were significantly shorter in the continuously positive and the negative-turn-positive than the continuously negative postoperative AFP-L3 group. CONCLUSION: Positive preoperative AFP-L3 and continuously positive or negative-turn-positive AFP-L3 results after surgery predicted a more aggressive tumor behavior, higher tumor recurrence, and poorer clinical outcomes. HCC patients with an increased proportion of AFP-L3 to total AFP should be more aggressively treated and closely followed-up.
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Authors | Xiao-Feng Zhang, Eric C H Lai, Xiao-Yan Kang, Hai-Hua Qian, Yan-Ming Zhou, Le-Hua Shi, Feng Shen, Ye-Fa Yang, Yu Zhang, Wan Yee Lau, Meng-Chao Wu, Zheng-Feng Yin |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 18
Issue 8
Pg. 2218-23
(Aug 2011)
ISSN: 1534-4681 [Electronic] United States |
PMID | 21336512
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Plant Lectins
- alpha-Fetoproteins
- lentil lectin
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Topics |
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Hepatocellular
(pathology, surgery)
- Female
- Follow-Up Studies
- Hepatectomy
- Humans
- Liver Neoplasms
(pathology, surgery)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(diagnosis, surgery)
- Plant Lectins
(metabolism)
- Prognosis
- Survival Rate
- alpha-Fetoproteins
(metabolism)
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