Unmanipulated haploidentical peripheral blood stem cell transplantation for precursor T-cell lymphoblastic lymphoma relapsed after autologous PBSCT.

Abstract

Precursor T-cell lymphoblastic lymphoma (T-LBL) is a clinically aggressive disease, associated with a high subsequent relapse rate. We treated a pediatric patient with T-LBL who relapsed after an autologous peripheral blood stem cell transplantation. Unmanipulated peripheral blood was used as a source for the graft. Hematopoietic engraftment was prompt and the risk of graft-versus-host disease was acceptable. The patient has been in continuous complete remission without chronic graft-versus-host disease for 32 months. Hence, haploidentical peripheral blood stem cell transplantation might be one of the adoptive options for salvage therapy in patients with recurrent or refractory T-LBL, and unmanipulated peripheral blood might be acceptable as a graft.

• Authors: Ying Zhou, Wenrong Huang, Honghua Li, Li Yu
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 33 Issue 3 Pg. 224-6 (Apr 2011) ISSN: 1536-3678 [Electronic] United States
• PMID: 21336164 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Granulocyte Colony-Stimulating Factor

Topics

• Child
• Graft vs Host Disease (etiology)
• Granulocyte Colony-Stimulating Factor (pharmacology)
• Haplotypes
• Humans
• Male
• Peripheral Blood Stem Cell Transplantation (adverse effects)
• Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (surgery)
• Recurrence
• Transplantation, Autologous