Trisomy 14 as a sole chromosome abnormality is associated with older age, a heterogenous group of myeloid neoplasms with dysplasia, and a wide spectrum of disease progression.

Abstract

Trisomy 14 is a rare recurrent cytogenetic abnormality in myeloid neoplasms; however, its clinicopathologic features have not been well described. We report the clinicopathologic, immunophenotypic, and molecular genetic features of 16 cases of myeloid neoplasms with isolated trisomy 14. Our results show that cases with isolated trisomy 14 encompass a heterogeneous group of myeloid neoplasms including myelodysplastic syndrome (MDS, 44%), myelodysplastic/myeloproliferative neoplasms (31%), and acute myeloid leukemia (25%). The patients are usually elder (median age 71 years), and there is a male predominance (82%). Multilineage dysplasia is noted in all cases. Oncogenic mutations of genes involved in cell proliferation and/or survival rarely occur. Compared with cases of MDS with diploid karyotype, patients of MDS with isolated trisomy 14 demonstrate a similar overall survival and rate of leukemia transformation.

• Authors: Wei Cui, Carlos E Bueso-Ramos, C Cameron Yin, Jianlan Sun, Su Chen, Ramya Muddasani, Gary Lu
• Journal: Journal of biomedicine & biotechnology (J Biomed Biotechnol) Vol. 2010 Pg. 365318 ( 2010) ISSN: 1110-7251 [Electronic] United States
• PMID: 21331167 (Publication Type: Journal Article)

Topics

• Age Factors
• Aged
• Aged, 80 and over
• Cell Growth Processes (physiology)
• Chromosome Aberrations
• Chromosomes, Human, Pair 14 (genetics)
• Diploidy
• Disease Progression
• Female
• Genetic Predisposition to Disease
• Humans
• Immunophenotyping
• Male
• Middle Aged
• Mutation
• Myelodysplastic Syndromes (genetics, pathology)
• Myelodysplastic-Myeloproliferative Diseases (genetics, pathology)
• Sex Factors
• Survival Analysis
• Trisomy (genetics, pathology)