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Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma.

Abstract
Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial-mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC.
AuthorsHidenori Shiraha, Shin-ichi Nishina, Kazuhide Yamamoto
JournalJournal of cellular biochemistry (J Cell Biochem) Vol. 112 Issue 3 Pg. 745-9 (Mar 2011) ISSN: 1097-4644 [Electronic] United States
PMID21328447 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2010 Wiley-Liss, Inc.
Chemical References
  • Core Binding Factor Alpha 3 Subunit
  • Runx3 protein, human
Topics
  • Animals
  • Carcinoma, Hepatocellular (metabolism, pathology)
  • Cell Cycle
  • Core Binding Factor Alpha 3 Subunit (genetics, physiology)
  • DNA Methylation
  • Down-Regulation
  • Epithelial-Mesenchymal Transition
  • Genes, Neoplasm
  • Humans
  • Liver Neoplasms (metabolism, pathology)
  • Loss of Heterozygosity
  • Neovascularization, Pathologic (metabolism)
  • Promoter Regions, Genetic

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