Abstract | RATIONALE: OBJECTIVE: METHODS: The method used was an assay to determine the efficacy of these drugs in moderating the reduction in prepulse inhibition of acoustic startle in mice treated with PCP and D: -amphetamine. RESULTS: The group II agonist LY354740 (5 and 10 mg/kg) moderated the effects of PCP on prepulse inhibition of acoustic startle in DBA/2 but not C57BL/6 mice. In contrast, two NAAG peptidase inhibitors, ZJ43 (150 mg/kg) and 2-PMPA (50, 100, and 150 mg/kg), did not significantly affect the PCP-induced reduction in prepulse inhibition in either strain. CONCLUSIONS: These data demonstrate that the efficacy of group II agonists in this model of sensory motor processing is strain-specific in mice. The difference between the effects of the group II agonist and the peptidase inhibitors in the DBA/2 mice may relate to the difference in efficacy of NAAG and the agonist at mGluR2.
|
Authors | Caterina P Profaci, Kristyn A Krolikowski, Rafal T Olszewski, Joseph H Neale |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 216
Issue 2
Pg. 235-43
(Jul 2011)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 21327758
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- 2-(phosphonomethyl)pentanedioic acid
- Bridged Bicyclo Compounds
- Excitatory Amino Acid Agonists
- Organophosphorus Compounds
- Receptors, Metabotropic Glutamate
- ZJ43
- Urea
- Glutamate Carboxypeptidase II
- Phencyclidine
- eglumetad
- Dextroamphetamine
|
Topics |
- Animals
- Bridged Bicyclo Compounds
(administration & dosage, pharmacology)
- Dextroamphetamine
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Excitatory Amino Acid Agonists
(administration & dosage, pharmacology)
- Glutamate Carboxypeptidase II
(antagonists & inhibitors)
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Organophosphorus Compounds
(administration & dosage, pharmacology)
- Phencyclidine
- Receptors, Metabotropic Glutamate
(agonists)
- Reflex, Startle
(drug effects)
- Schizophrenia
(drug therapy, physiopathology)
- Species Specificity
- Urea
(analogs & derivatives, pharmacology)
|