Infectious mononucleosis with atypical manifestations accompanied by transient IgM antibody response for cytomegalovirus.

Abstract

Infectious mononucleosis (IM) is a clinical syndrome caused by primary infection with Epstein-Barr virus (EBV) that is common in adolescents. In adults, particularly in elderly people, the clinical picture of IM tends to be atypical, often leading to a diagnostic challenge. Diagnosis is also complicated because infection with EBV can induce the synthesis of cross-reacting immunoglobulin M antibodies for other herpesviruses. We report an unusual case of infectious mononucleosis in a 34-year-old immunocompetent adult. Epidemiological studies indicate that the average age of primary EBV infection in developed countries is increasing. IM with atypical presentation will be a diagnostic challenge in the future as the number of EBV-naïve adults increases.

• Authors: Jun Nishikawa, Hisashi Funada, Takako Miyazaki, Haruka Fujinami, Takayoshi Miyazono, Jun Murakami, Takahiko Kudo, Toshiro Sugiyama
• Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 17 Issue 5 Pg. 686-8 (Oct 2011) ISSN: 1437-7780 [Electronic] Netherlands
• PMID: 21327688 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Viral
• Immunoglobulin M

Topics

• Adult
• Antibodies, Viral (blood)
• Cytomegalovirus (immunology)
• Cytomegalovirus Infections (diagnosis, immunology, virology)
• Herpesvirus 4, Human (immunology)
• Humans
• Immunoglobulin M (blood)
• Infectious Mononucleosis (diagnosis, immunology, virology)
• Male