Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery.

Abstract

The synthesis and biological efficacy of novel nanomicelles that rapidly disassemble and release their encapsulated payload intracellularly under tumor-relevant glutathione (GSH) levels are reported. The unique design includes a PEG-sheddable shell and poly(ε-benzyloxycarbonyl-l-lysine) core with a redox-sensitive disulfide linkage.

• Authors: Hui-Yun Wen, Hai-Qing Dong, Wen-juan Xie, Yong-Yong Li, Kang Wang, Giovanni M Pauletti, Dong-Lu Shi
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 47 Issue 12 Pg. 3550-2 (Mar 28 2011) ISSN: 1364-548X [Electronic] England
• PMID: 21327187 (Publication Type: Journal Article)

Chemical References

• Coated Materials, Biocompatible
• Disulfides
• Drug Carriers
• Micelles
• Polylysine
• poly(N(epsilon)-benzyloxycarbonyl-L-lysine)
• Polyethylene Glycols
• Doxorubicin
• Glutathione

Topics

• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Coated Materials, Biocompatible (chemistry)
• Disulfides (chemistry)
• Doxorubicin (metabolism, pharmacology)
• Drug Carriers (chemistry)
• Glutathione (chemistry)
• Humans
• Intracellular Space (metabolism)
• Kinetics
• Micelles
• Nanostructures (chemistry)
• Polyethylene Glycols (chemistry)
• Polylysine (analogs & derivatives, chemistry)