Virilization of a female infant by a maternal adrenocortical carcinoma.

Abstract

OBJECTIVE:

To describe a possible mechanism underlying the partial virilization of a 46, XX infant by a functional maternal adrenocortical carcinoma (ACC).

METHODS:

We performed immunocytochemical staining of tumor sections for luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors. In addition, related reports in the literature are discussed.

RESULTS:

A previously healthy mother developed a large cortisol- and androgen-producing stage III adrenal tumor that did not interfere with conception or early morphogenesis. The tumor eluded detection until after delivery of a partially virilized 46, XX female infant with ambiguous genitalia. Immunohistochemical staining of tumor sections revealed overexpression of the LH/hCG receptor. Virilization of the genetically female fetus may have resulted from hCG-stimulated steroid secretion by the ACC.

CONCLUSION:

Because hypercortisolism and hyperandrogenism are associated with menstrual disturbances and spontaneous abortion, pregnancy in patients with functional adrenal tumors is uncommon. Rarely, maternal steroid excess from a functional adrenal tumor has caused 46, XX disordered sex differentiation. This unusual case demonstrates the influence of hCG on the functionality of an ACC and demonstrates the rare phenomenon of virilization of a female infant by a functional maternal adrenal tumor.

• Authors: Lilah F Morris, Steven Park, Timothy Daskivich, Bernard M Churchill, C V Rao, Zhenmin Lei, Dorothy S Martinez, Michael W Yeh
• Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists (Endocr Pract) 2011 Mar-Apr Vol. 17 Issue 2 Pg. e26-31 ISSN: 1934-2403 [Electronic] United States
• PMID: 21324830 (Publication Type: Case Reports, Journal Article)

Chemical References

• Receptors, LH

Topics

• Adrenal Gland Neoplasms (complications, metabolism)
• Adrenocortical Carcinoma (complications, metabolism)
• Female
• Humans
• Immunohistochemistry
• Infant, Newborn
• Pregnancy
• Pregnancy Complications
• Receptors, LH (metabolism)
• Virilism (etiology, genetics)
• Young Adult