[A clinical study on the effectiveness of desensitizing toothpaste in patients with dentine hypersensitivity].

Abstract

OBJECTIVE:

To evaluate the effectiveness of desensitizing toothpaste containing 5.53% potassium citrate on dentine hypersensitivity.

METHODS:

This was a randomized, double-blinded, controlled, clinical trial. Those, who satisfied the inclusion criteria, were recruited into the study and randomized allocated into test group and control group according to gender and age group. At baseline, 67 subjects (36 in test group, 31 in control group) were recruited into the study. The dentine hypersensitivity was evaluated by a subject self-perceived short, sharp pain in visual analogue scale (VAS) in response to a blast of cold air from a triple syringe administered to a tooth surface in 1 cm. Test toothpastes, containing 5.53% potassium citrate and 0.76% sodium monofluorophosphate, and control toothpastes, containing only 0.76% sodium monofluorophosphate were delivered to the study subjects in the test and control group respectively. The subjects were asked to brush their teeth twice a day, and at least one minute each time. During the 8-week study period, a subjective evaluation of changes in the individuals overall sensitivity to everyday stimuli was also scored in VAS.

RESULTS:

At the end of the trial data of 57 subjects (31 in test group, 26 in control group) was used for analysis. From baseline to 8-week evaluation, the mean VAS values to cold air and subjects' self-perceived VAS values of the subjects decreased both in the test and control groups. Furthermore, the reduction in mean VAS values to cold air from baseline to 4-week of the test subjects was statistically significant higher than that of the control (1.12 vs. 0.32, P<0.05). The reduction in mean subjects' self-perceived VAS values from baseline to 8-week of the test subjects was statistically significant higher than that of the control (1.59 vs. 0.24, P<0.05).

CONCLUSION:

RESULTS of the clinical trial showed that toothpastes containing 5.53% potassium citrate were effective in reducing dentine hypersensitivity.

• Authors: Yan Liang, Wen sheng Rong, Wei jian Wang, Li hong Ge
• Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences (Beijing Da Xue Xue Bao Yi Xue Ban) Vol. 43 Issue 1 Pg. 112-6 (Feb 18 2011) ISSN: 1671-167X [Print] China
• PMID: 21321633 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Phosphates
• Toothpastes
• fluorophosphate
• Potassium Citrate
• Fluorides

Topics

• Adolescent
• Adult
• Dentin Sensitivity (drug therapy)
• Double-Blind Method
• Female
• Fluorides (administration & dosage)
• Humans
• Male
• Middle Aged
• Pain Measurement
• Phosphates (administration & dosage)
• Potassium Citrate (administration & dosage)
• Toothpastes (chemistry)
• Young Adult