Evaluation of factors associated with second remission in dogs with lymphoma undergoing retreatment with a cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy protocol: 95 cases (2000-2007).

Abstract

OBJECTIVE:

To evaluate factors associated with second remission in dogs with lymphoma retreated with a cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) protocol after relapse following initial treatment with a first-line 6-month CHOP protocol.

DESIGN:

Retrospective case series.

ANIMALS:

95 dogs with lymphoma.

PROCEDURES:

Medical records were reviewed. Remission duration was estimated by use of the Kaplan-Meier method. Factors potentially associated with prognosis were examined.

RESULTS:

Median remission duration after the first-line CHOP protocol was 289 days (range, 150 to 1,457 days). Overall, 78% (95% confidence interval [CI], 69% to 86%) of dogs achieved a complete remission following retreatment, with a median second remission duration of 159 days (95% CI, 126 to 212 days). Duration of time off chemotherapy was associated with likelihood of response to retreatment; median time off chemotherapy was 140 days for dogs that achieved a complete remission after retreatment and 84 days for dogs that failed to respond to retreatment. Second remission duration was associated with remission duration after initial chemotherapy; median second remission duration for dogs with initial remission duration ≥ 289 days was 214 days (95% CI, 168 to 491 days), compared with 98 days (95% CI, 70 to 144 days) for dogs with initial remission duration < 289 days.

CONCLUSIONS AND CLINICAL RELEVANCE:

Findings suggested that retreatment with the CHOP protocol can be effective in dogs with lymphoma that successfully complete an initial 6-month CHOP protocol.

• Authors: Andrea B Flory, Kenneth M Rassnick, Hollis N Erb, Laura D Garrett, Nicole C Northrup, Kim A Selting, Brenda S Phillips, Jennifer E Locke, John D Chretin
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 238 Issue 4 Pg. 501-6 (Feb 15 2011) ISSN: 0003-1488 [Print] United States
• PMID: 21320021 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Animals
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Cyclophosphamide (administration & dosage, therapeutic use)
• Dog Diseases (drug therapy)
• Dogs
• Doxorubicin (administration & dosage, therapeutic use)
• Drug Administration Schedule
• Lymphoma (drug therapy, veterinary)
• Prednisone (administration & dosage, therapeutic use)
• Remission Induction
• Retrospective Studies
• Vincristine (administration & dosage, therapeutic use)