Abstract | BACKGROUND:
Lymphangiectases are a histologic sign of lymphostasis, which is associated with decreased immune cell trafficking and cell-mediated immunity. OBJECTIVE: MATERIALS AND METHODS: The number and maximal dilation of lymphangiectases were measured in the upper half of the dermis of 51 consecutive biopsies of warts, 230 consecutive normal skin samples from primary skin tumor excisions, and 14 normal skin samples from breast reduction (11) and panniculectomy (3) specimens. RESULTS: All warts had one or more underlying lymphangiectases compared with 79% of peritumor normal skin samples and 50% of cosmetic specimens. The mean number of lymphangiectases and mean maximal dilation were significantly greater in warts than in peritumor skin, which was significantly greater than cosmetic skin samples (3.6 vs. 1.3 vs. 0.12 lymphangiectases per square millimeter and 54 vs. 23 vs. 1 μm, respectively; P = 0.0001). Warts exhibited mild fibrosis significantly more frequently than peritumor skin (57% vs. 5%; P = 0.0001). For peritumor (normal) skin, age, solar elastosis, and adjacent malignancy correlated with greater dilation of lymphatics. Solar elastosis also correlated with increased number of lymphangiectases. CONCLUSIONS:
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Authors | Joan Paul, J Andrew Carlson |
Journal | The American Journal of dermatopathology
(Am J Dermatopathol)
Vol. 33
Issue 2
Pg. 152-60
(Apr 2011)
ISSN: 1533-0311 [Electronic] United States |
PMID | 21317613
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Child
- Child, Preschool
- Female
- Humans
- Immunologic Surveillance
(immunology)
- Lymphangiectasis
(immunology, pathology)
- Male
- Middle Aged
- Skin Aging
(immunology, pathology)
- Skin Diseases
(immunology, pathology)
- Skin Neoplasms
(pathology)
- Warts
(immunology, pathology)
- Young Adult
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