The probiotic Escherichia coli Nissle 1917 reduces pathogen invasion and modulates cytokine expression in Caco-2 cells infected with Crohn's disease-associated E. coli LF82.

Abstract

Increased numbers of adherent invasive Escherichia coli (AIEC) have been found in Crohn's disease (CD) patients. In this report, we investigate the potential of the probiotic Escherichia coli Nissle 1917 (EcN) to reduce features associated with AIEC pathogenicity in an already established infection with AIEC reference strain LF82.

• Authors: Claudia Huebner, Yaoyao Ding, Ivonne Petermann, Christoph Knapp, Lynnette R Ferguson
• Journal: Applied and environmental microbiology (Appl Environ Microbiol) Vol. 77 Issue 7 Pg. 2541-4 (Apr 2011) ISSN: 1098-5336 [Electronic] United States
• PMID: 21317252 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines

Topics

• Antibiosis
• Caco-2 Cells
• Crohn Disease (microbiology)
• Cytokines (metabolism)
• Epithelial Cells (immunology, microbiology)
• Escherichia coli (growth & development, pathogenicity)
• Escherichia coli Infections (microbiology)
• Humans
• Probiotics