Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin.

Abstract

Biological therapies can be beneficial in cancer patients. The present study aims to examine the inhibitory mechanism of curcumin on cancer cells in patients with colorectal cancer. The results showed that curcumin administration increased body weight, decreased serum TNF-alpha levels, increased apoptotic tumor cells, enhanced expression of p53 molecule in tumor tissue, and modulated tumor cell apoptotic pathway. We conclude that the curcumin treatment improves the general health of patients with colorectal cancer via the mechanism of increased p53 molecule expression in tumor cells and consequently speeds up tumor cell apoptosis.

• Authors: Zhen-Yu He, Chuan-Bing Shi, Hao Wen, Fang-Long Li, Bao-Lin Wang, Jie Wang
• Journal: Cancer investigation (Cancer Invest) Vol. 29 Issue 3 Pg. 208-13 (Mar 2011) ISSN: 1532-4192 [Electronic] England
• PMID: 21314329 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Antineoplastic Agents
• Tumor Necrosis Factor-alpha
• Tumor Suppressor Protein p53
• Curcumin

Topics

• Antineoplastic Agents (therapeutic use)
• Apoptosis (drug effects)
• Body Weight (drug effects)
• Cachexia (drug therapy, etiology)
• Colorectal Neoplasms (complications, drug therapy, metabolism)
• Combined Modality Therapy
• Curcumin (therapeutic use)
• Digestive System Surgical Procedures
• Double-Blind Method
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunohistochemistry
• In Situ Nick-End Labeling
• Male
• Neoplasm Staging
• Radiotherapy
• Tumor Necrosis Factor-alpha (blood)
• Tumor Suppressor Protein p53 (drug effects, metabolism)
• Up-Regulation