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[Ectopic hormone production of beta-subunit of human chorionic gonadotropin by cells of signet ring cell carcinoma of the stomach].

Abstract
The ectopic hormone production by tumor cells that have a light optical structure of typical non-endocrine cancers has long attracted the attention of investigation all over the world. Specifically, this concerns the phenomenon of the ectopic production of the beta-subunit of human chorionic gonadotropin (beta-hCG) by non-germinogenic tumors, which is, according to R.K. Iles's data, encountered in 20-40% of malignant epithelial tumors. Despite the fact that beta-hCG synthesis is traditionally regarded as the prerogative of germinogenic tumors, the world's literature contains strong evidence for latent beta-hCG gene expression and many cases of clinically evident manifestation of the effects of chorionic gonadotropin. The latter fact, if a clinician and a pathologist are unaware of the behavior of a tumor, may give rise to a diagnostic error and incorrect treatment policy.
AuthorsA I Karseladze, N A Kozlov
JournalArkhiv patologii (Arkh Patol) 2010 Sep-Oct Vol. 72 Issue 5 Pg. 36-9 ISSN: 0004-1955 [Print] Russia (Federation)
PMID21313767 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Chorionic Gonadotropin, beta Subunit, Human
Topics
  • Adult
  • Carcinoma, Signet Ring Cell (metabolism)
  • Chorionic Gonadotropin, beta Subunit, Human (biosynthesis)
  • Humans
  • Male
  • Stomach Neoplasms (metabolism)

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