Abstract |
The ectopic hormone production by tumor cells that have a light optical structure of typical non- endocrine cancers has long attracted the attention of investigation all over the world. Specifically, this concerns the phenomenon of the ectopic production of the beta-subunit of human chorionic gonadotropin (beta-hCG) by non-germinogenic tumors, which is, according to R.K. Iles's data, encountered in 20-40% of malignant epithelial tumors. Despite the fact that beta-hCG synthesis is traditionally regarded as the prerogative of germinogenic tumors, the world's literature contains strong evidence for latent beta-hCG gene expression and many cases of clinically evident manifestation of the effects of chorionic gonadotropin. The latter fact, if a clinician and a pathologist are unaware of the behavior of a tumor, may give rise to a diagnostic error and incorrect treatment policy.
|
Authors | A I Karseladze, N A Kozlov |
Journal | Arkhiv patologii
(Arkh Patol)
2010 Sep-Oct
Vol. 72
Issue 5
Pg. 36-9
ISSN: 0004-1955 [Print] Russia (Federation) |
PMID | 21313767
(Publication Type: Case Reports, English Abstract, Journal Article)
|
Chemical References |
- Chorionic Gonadotropin, beta Subunit, Human
|
Topics |
- Adult
- Carcinoma, Signet Ring Cell
(metabolism)
- Chorionic Gonadotropin, beta Subunit, Human
(biosynthesis)
- Humans
- Male
- Stomach Neoplasms
(metabolism)
|