Abstract |
Cardiopulmonary biomarkers are biological parameters that can be objectively measured and quantified as indicators of pathogenic processes ( heartworm disease) or as indicators of response to therapeutic intervention. To determine levels of cardiopulmonary biomarkers in canine dirofilariasis, measurements of cardiac troponin T, cardiac troponin I, myoglobin, and D-dimer concentrations were performed for dogs with and without evidence of adult heartworm infection. The results showed that levels of cardiac troponin T were undetectable in all dogs studied while levels of cardiac troponin I were higher in dogs infected with Dirofilaria immitis. In healthy dogs, levels of myoglobin and D-dimer were below detection limits of the instrument and were significantly higher in heartworm-infected dogs, notably in microfilaremic dogs. The results suggest the possibility of using troponin I and myoglobin as markers for cardiac damage and the D-dimer as a supportive tool for a diagnosis of pulmonary thromboembolism in dogs with cardiopulmonary dirofilariasis.
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Authors | E Carretón, J A Corbera, M C Juste, R Morchón, F Simón, J A Montoya-Alonso |
Journal | Veterinary parasitology
(Vet Parasitol)
Vol. 176
Issue 4
Pg. 313-6
(Mar 22 2011)
ISSN: 1873-2550 [Electronic] Netherlands |
PMID | 21310535
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- Fibrin Fibrinogen Degradation Products
- Myoglobin
- Troponin I
- Troponin T
- fibrin fragment D
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Topics |
- Animals
- Biomarkers
(blood)
- Case-Control Studies
- Dirofilaria immitis
(pathogenicity)
- Dirofilariasis
(diagnosis, parasitology, pathology)
- Dog Diseases
(diagnosis, parasitology, pathology)
- Dogs
- Female
- Fibrin Fibrinogen Degradation Products
(analysis)
- Male
- Myocardium
(pathology)
- Myoglobin
(blood)
- Pulmonary Embolism
(diagnosis)
- Troponin I
(blood)
- Troponin T
(blood)
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