Abstract | BACKGROUND AND OBJECTIVE: METHODS: RESULTS: The DM group presented high levels of SOD and GPx enzymes, which were reduced by acarbose treatment. Tissue damage, which was indicated by an increased MDA concentration in the parotid glands of rats in the DM group, was also reversed in the DMA group. Moreover, type I collagen fibres from DM rats were more intensely stained than those of NDM rats. Acarbose treatment was effective in decreasing collagen deposition, which was shown by a decrease in staining intensity of approximately 25%. CONCLUSIONS: These results suggest that the diabetic state influences the type I collagen concentration in the parotid glands of rats. In addition, acarbose treatment was helpful in preventing the deposition of such fibres, as well the increase in oxidative stress induced by hyperglycemia.
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Authors | Simone Ramos Deconte, Renato José da Silva Oliveira, Luciana Karen Calábria, Vanessa Neves de Oliveira, Neire Moura de Gouveia, Alberto da Silva Moraes, Foued Salmen Espindola |
Journal | Archives of oral biology
(Arch Oral Biol)
Vol. 56
Issue 8
Pg. 744-51
(Aug 2011)
ISSN: 1879-1506 [Electronic] England |
PMID | 21310393
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antioxidants
- Biomarkers
- Blood Glucose
- Blood Proteins
- Collagen Type I
- Free Radical Scavengers
- Hypoglycemic Agents
- Triglycerides
- Malondialdehyde
- Streptozocin
- Urea
- Cholesterol
- Creatinine
- Glutathione Peroxidase
- Superoxide Dismutase
- gamma-Glutamyltransferase
- Aspartate Aminotransferases
- Alanine Transaminase
- Alkaline Phosphatase
- Acarbose
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Topics |
- Acarbose
(therapeutic use)
- Alanine Transaminase
(blood)
- Alkaline Phosphatase
(blood)
- Animals
- Antioxidants
(analysis)
- Aspartate Aminotransferases
(blood)
- Biomarkers
(analysis)
- Blood Glucose
(analysis)
- Blood Proteins
(analysis)
- Cholesterol
(blood)
- Collagen Type I
(drug effects)
- Creatinine
(blood)
- Diabetes Mellitus, Experimental
(blood, drug therapy)
- Free Radical Scavengers
(analysis)
- Glutathione Peroxidase
(drug effects)
- Hypoglycemic Agents
(therapeutic use)
- Male
- Malondialdehyde
(analysis)
- Oxidative Stress
(drug effects)
- Parotid Gland
(drug effects, pathology)
- Rats
- Rats, Wistar
- Streptozocin
- Superoxide Dismutase
(drug effects)
- Triglycerides
(blood)
- Urea
(blood)
- gamma-Glutamyltransferase
(blood)
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