Portal vein thrombosis as complication of romiplostim treatment in a cirrhotic patient with hepatitis C-associated immune thrombocytopenic purpura.

Thrombopoietin receptor agonists are a new class of compounds licenced for the treatment of immune thrombocytopenic purpura. They are currently being studied for patients with thrombopenia in advanced liver disease or under therapy for hepatitis C. There are indications that the risk for development of portal vein thrombosis in patients with advanced liver cirrhosis might be increased under therapy with thrombopoietin receptor agonists. We report a case of a patient with Child class B liver cirrhosis with concurrent immune thrombocytopenic purpura that developed portal vein thrombosis under therapy with the thrombopoietin receptor agonist romiplostim.
A 50-year-old woman with hepatitis C virus associated immune thrombocytopenic purpura and Child class B liver cirrhosis presented in our emergency with rapidly evolving hydropic decompensation and general malaise. For immune thrombocytopenic purpura, the patient was started on the thrombopoietin receptor agonist romiplostim nine months ago.
During hospitalization, the platelet count was measured above 330,000/μl and partial portal vein thrombosis was diagnosed by imaging studies. The thrombotic event was assumed to be associated with the romiplostim treatment for immune thrombocytopenic purpura via excessive elevation of platelet count. After anticoagulation with heparin and cessation of romiplostim treatment, complete recanalisation of the portal vein was achieved.
We conclude that romiplostim should be used with precaution in patients with hepatitis C-associated immune thrombocytopenic purpura and advanced liver cirrhosis as the risk for thrombotic complications may increase significantly.
AuthorsGeorg Dultz, Bernd Kronenberger, Alireza Azizi, Ulrike Mihm, Thomas J Vogl, Ulrike Sarrazin, Christoph Sarrazin, Stefan Zeuzem, Wolf-Peter Hofmann
JournalJournal of hepatology (J Hepatol) Vol. 55 Issue 1 Pg. 229-32 (Jul 2011) ISSN: 1600-0641 [Electronic] England
PMID21310200 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Receptors, Fc
  • Receptors, Thrombopoietin
  • Recombinant Fusion Proteins
  • romiplostim
  • Thrombopoietin
  • Angiography, Digital Subtraction
  • Female
  • Hepatitis C, Chronic (complications)
  • Humans
  • Liver Cirrhosis (complications)
  • Middle Aged
  • Portal Vein
  • Purpura, Thrombocytopenic, Idiopathic (complications, drug therapy)
  • Receptors, Fc
  • Receptors, Thrombopoietin (agonists)
  • Recombinant Fusion Proteins (adverse effects)
  • Risk Factors
  • Thrombopoietin (adverse effects)
  • Tomography, X-Ray Computed
  • Venous Thrombosis (etiology, radiography)

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