Abstract | OBJECTIVE: MATERIAL AND METHODS: In 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment: C ( n=30) - subgingival irrigation with 1 mL of saline; T ( n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05). RESULTS: In the histometric analysis, at 7, 15 and 30 days, Group T (0.72 ± 0.05 mm², 0.57 ± 0.14 mm², 0.62 ± 0.07 mm²), showed less bone loss (p<0.05) than Group C (1.35 ± 0.25 mm²; 1.40 ± 0.31 mm²; 1.29 ± 0.27 mm²), respectively. CONCLUSIONS: Subgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats.
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Authors | Leandro Araújo Fernandes, Thiago Marchi Martins, Juliano Milanezi de Almeida, Maria José Hitomi Nagata, Leticia Helena Theodoro, Valdir Gouveia Garcia, Alvaro Francisco Bosco |
Journal | Journal of applied oral science : revista FOB
(J Appl Oral Sci)
Vol. 18
Issue 6
Pg. 635-40
(Dec 2010)
ISSN: 1678-7765 [Electronic] Brazil |
PMID | 21308297
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Tetracycline
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Topics |
- Analysis of Variance
- Animals
- Anti-Bacterial Agents
(therapeutic use)
- Combined Modality Therapy
- Dental Scaling
- Male
- Periodontitis
(chemically induced, drug therapy)
- Rats
- Rats, Wistar
- Root Planing
- Tetracycline
(therapeutic use)
- Therapeutic Irrigation
- Time Factors
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