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Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats.

AbstractOBJECTIVE:
The aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (TTC-HCL) as adjunctive treatment to scaling and root planning (SRP) on induced periodontitis in rats.
MATERIAL AND METHODS:
In 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment: C (n=30) - subgingival irrigation with 1 mL of saline; T (n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05).
RESULTS:
In the histometric analysis, at 7, 15 and 30 days, Group T (0.72 ± 0.05 mm², 0.57 ± 0.14 mm², 0.62 ± 0.07 mm²), showed less bone loss (p<0.05) than Group C (1.35 ± 0.25 mm²; 1.40 ± 0.31 mm²; 1.29 ± 0.27 mm²), respectively.
CONCLUSIONS:
Subgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats.
AuthorsLeandro Araújo Fernandes, Thiago Marchi Martins, Juliano Milanezi de Almeida, Maria José Hitomi Nagata, Leticia Helena Theodoro, Valdir Gouveia Garcia, Alvaro Francisco Bosco
JournalJournal of applied oral science : revista FOB (J Appl Oral Sci) Vol. 18 Issue 6 Pg. 635-40 (Dec 2010) ISSN: 1678-7765 [Electronic] Brazil
PMID21308297 (Publication Type: Evaluation Study, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Tetracycline
Topics
  • Analysis of Variance
  • Animals
  • Anti-Bacterial Agents (therapeutic use)
  • Combined Modality Therapy
  • Dental Scaling
  • Male
  • Periodontitis (chemically induced, drug therapy)
  • Rats
  • Rats, Wistar
  • Root Planing
  • Tetracycline (therapeutic use)
  • Therapeutic Irrigation
  • Time Factors

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