Functional interpretation of the kidney juxtaglomerular apparatus using renin immunohistochemistry in Bartter's, pseudo-Bartter's and Conn's syndromes.

Abstract

A comparative study of renin immunoreactivity in the juxtaglomerular apparatus of the human kidney was performed using the indirect immunoperoxidase method on a random microscopic sections. In renal biopsies taken from a case of Bartter's syndrome and a case of pseudo-Bartter's syndrome, the number of renin-positive juxtaglomerular apparatus (JGA) and the number of renin-positive cells in each JGA were significantly greater than in five renal specimens from control autopsy cases. In Conn's syndrome, none of the glomeruli contained renin-immunoreactive JGA. The number of renin-positive cells/mm2 in the renal cortex in cases of Bartter's and pseudo-Bartter's syndromes were 17.5 and 20.3, respectively, while in the control group, the range was 0.78-1.77 (mean 1.08). Together with other histochemical findings routinely examined in renal specimens, renin immunohistochemistry on random sections may be helpful in diagnostic renal pathology.

• Authors: N Lertprasertsuke, K Kakudo, Y Osamura, Y Nomoto, H Sakai, K Watanabe
• Journal: The Tokai journal of experimental and clinical medicine (Tokai J Exp Clin Med) Vol. 15 Issue 4 Pg. 317-26 (Jul 1990) ISSN: 0385-0005 [Print] Japan
• PMID: 2130539 (Publication Type: Case Reports, Journal Article)

Chemical References

• Renin

Topics

• Adult
• Bartter Syndrome (metabolism, pathology, physiopathology)
• Female
• Humans
• Hyperaldosteronism (metabolism, pathology, physiopathology)
• Immunohistochemistry
• Juxtaglomerular Apparatus (chemistry, physiopathology, ultrastructure)
• Microscopy, Electron
• Microscopy, Immunoelectron
• Middle Aged
• Renin (analysis)