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[Efficacy of naftopidil in patients with overactive bladder associated with benign prostatic hyperplasia: prospective randomized controlled study to compare differences in efficacy between morning and evening medication].

Abstract
A total of 100 patients with benign prostatic hyperplasia (BPH) and overactive bladder (OAB) symptoms (BPH/OAB), enrolled between June 2006 to March 2008, were randomly divided into 2 groups of morning medication (M) and evening medication (E) groups, then 50 mg of naftopidil was given once a day after breakfast or supper for 8 weeks. Data were available for efficacy analysis on 80 patients (M group ; 43, E group ; 37). Naftopidil significantly improved the overall international prostatic symptom score ; from 19.2±7.9 to 11.7±5.8 in the M group and from 19.4±6.4 to 12.3±6.8 in the E group (p<0.0001), QOL score from 4.9±0.8 to 3.2±1.4 in the M group and from 5.0±0.8 to 3.6±1.3 in the E group (p<0.0001), and OAB symptom score from 7.8±2.6 to 5.0±2.5 in the M group (p<0.0001) and from 8.6±2.9 to 5.8± 3.3 in the E group (p<0.0001). There was no significant difference in the incidence of adverse effects between the M group (6.1%) and E group (2.2%). These results suggest that naftopidil improves storage symptoms as well as voiding symptoms regardless of timing of administration.
AuthorsHideki Sakai, Tsukasa Igawa, Toru Onita, Masataka Furukawa, Tomoaki Hakariya, Mikio Hayashi, Fukuzo Matsuya, Yohei Shida, Naoki Nishimura, Yasuo Yogi, Toshifumi Tsurusaki, Kousuke Takehara, Koichiro Nomata, Kazutaka Shiraishi, Takefumi Shono, Daiyu Aoki, Hiroshi Kanetake
JournalHinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 57 Issue 1 Pg. 7-13 (Jan 2011) ISSN: 0018-1994 [Print] Japan
PMID21304253 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Adrenergic alpha-Antagonists
  • Naphthalenes
  • Piperazines
  • naftopidil
Topics
  • Adrenergic alpha-Antagonists (administration & dosage, adverse effects)
  • Aged
  • Aged, 80 and over
  • Drug Administration Schedule
  • Humans
  • Male
  • Middle Aged
  • Naphthalenes (administration & dosage, adverse effects)
  • Piperazines (administration & dosage, adverse effects)
  • Prostatic Hyperplasia (complications, drug therapy)
  • Urinary Bladder, Overactive (drug therapy, etiology)

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