Abstract | UNLABELLED: METHODS: Patients from a single center who had CTX from 1990 to 2007 and who were converted to sirolimus and a dose-reduced CNI were compared to group-matched controls maintained on CNI and an antiproliferative agent. RESULTS: One hundred and fifty-five patients (79 sirolimus and 76 controls) were included and had similar baseline characteristics. Sirolimus was started a mean of 1429 d post-CTX and maintained for a mean of 823 d. Reason for conversion to sirolimus was renal insufficiency (34%), vasculopathy (29%), recurrent rejection (19%), and other (18%). The eGFR was not different between groups at baseline (44.7 mL/min/1.73 m(2) vs. 46.0, p = 0.64) or at any point during follow-up: 90 d, 180 d, 1 yr, 2 yr, and 3 yr. conclusion: Patients converted to a regimen of sirolimus and a dosed-reduced CNI have stable renal function over the following three yr, but do not have an improvement in renal outcomes compared to patients maintained on full dose CNI.
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Authors | Sameer J Khandhar, Hemal V Shah, Michael A Shullo, Rachelle Zomak, Michelle Navoney, Dennis M McNamara, Robert L Kormos, Yoshiya Toyoda, Jeffrey J Teuteberg |
Journal | Clinical transplantation
(Clin Transplant)
2012 Jan-Feb
Vol. 26
Issue 1
Pg. 42-9
ISSN: 1399-0012 [Electronic] Denmark |
PMID | 21303417
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2011 John Wiley & Sons A/S. |
Chemical References |
- Calcineurin Inhibitors
- Immunosuppressive Agents
- Sirolimus
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Topics |
- Calcineurin Inhibitors
- Case-Control Studies
- Female
- Glomerular Filtration Rate
- Graft Rejection
(prevention & control)
- Heart Transplantation
(adverse effects, immunology)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Kidney Failure, Chronic
(drug therapy, etiology)
- Kidney Function Tests
- Male
- Middle Aged
- Prognosis
- Prospective Studies
- Retrospective Studies
- Sirolimus
(therapeutic use)
- Time
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